Name of the speaker: Yong Chen
Position: Professor

Company/Organization: Ecole Normale Supérieure (ENS), Paris, France
Institute of Biomedical Engineering and Technology, CAS, Suzhou, China


The Title of Speech: Nano-manufacturing of extracellular-matrix mimicking devices

Biography of the Speaker: Yong Chen received his Ph.D. in Condensed Matter Physics from the University of Montpellier in 1986. After three years at the Scuola Normale Superiorie di Pisa and Peking University, he became a researcher of the French National Centre for Scientific Research (CNRS) in 1990 and then moved to the Ecole Normale Supérieure (ENS), Department of Chemistry, in 2003. He is now also Adjunct Professor of Kyoto University (iCeMS) and Changjiang Chair Professor of Peking University (QBC), and Guest Professor of Jianghan University (IIR) and Institute of Biomedical Engineering and Technology of Chinese Academy of Science (SIBET). Over 30 years, Yong Chen has been worked in different fields of nanosciences and nanotechnologies and he is now focused on applications of microfluidics and nanofabrication technologies for biomedical research, diagnosis and regenerative medicine.

Abstract of Speech: Tao follows Nature (道德经, 老子). By mimicking the organization of in vivo extracellular matrix, we designed a variety of culture substrates by using both nature and synthetic biopolymers and both conventional and non-conventional nanofabrication techniques. Most recently, we proposed a patch form culture device made of monolayer of crosslinked nanofibers which can be used for high efficiency differentiation of human induced pluripotent stem cells, showing numerous advantages over the conventional culture dish method. In this talk, I will first introduce the concepts and approaches in nano-manufacturing of extracellular-matrix mimicking devices. Then, I will show the results of our patch form culture for regenerative medicine and drug assessment. Finally, I will discuss the most critical issues related to the organs on a chip and body on a chip, taking into account the advantage of the pluripotent stem cells and the power of the patch form culture devices as well as the potential of microfluidic system automation.