Name of the speaker: Peixuan Guo
Position: Professor
Company/Organization: Ohio State University

The Title of Speech: Nanomotor and RNA Nanotechnology for Single Molecule Sensing,  Drug Development, Biocomputer Modules, Material Industry and Nanomedicine

Biography of the Speaker: Dr. Peixuan Guo has held three endowed chair positions at three universities. He currently is the Sylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery at OSU. He received his Ph.D. from U of Minnesota, then postdoctoral training at NIH. He was an Assistant Professor at Purdue in 1990, tenured in 1993, became full Professor in 1997 and honored  Purdue faculty scholar in 1998. He was the Director of NIH Nanomedicine Development Center from 2006-2011 and director of the U Kentucky Nanobiotech Center from 2012-2015; current Director of NCI CNPP: RNA Nanotech for Cancer Therapy. He constructed the first viral DNA packaging motor (PNAS 1986), discovered phi29 motor pRNA (Science 1987); revealed  pRNA hexamer (Mol Cell 1998), pioneered RNA nanotechnology (Mol Cell 1998, featured in Cell 1998;Nature Nanotech 2010,2011); built a system to detect single-fluorophores (EMBOJ  2007); incorporated phi29 motor channel into membrane (Nature Nanotech 2009) for single pore sensing and DNA sequencing; discovered a third class of biomotor using revolution mechanism; developed approaches for ultra-potent drugs development; received Pfizer Distinguished Faculty Award; Purdue Faculty Scholar Award; Lions Club Cancer Res Award; Distinguished Alumni of U Minnesota; 100 Years Distinguished Chinese Alumni of U Minnesota; editorial board of 7 nanotech journals; reported numerous times by TV such as ABC, and NBC, featured by NIH, NSF, MSNBC, NCI and ScienceNow; member of two prominent national nanotech initiatives by NSF and NIH; Intramural Site-visit Review Panel twice for NIH/NCI; Examination Panel of Chinese National Academy of Sciences since 2014.

Abstract of Speech: Biomotors are involved in countless vital active processes including muscle motion, heart beating, lung breathing, DNA replication, cell division and viral DNA packaging. When I was a graduate student, I discovered an RNA molecule that drives the viral DNA packaging motor. Subsequently, I constructed the active viral DNA packaging motor in vitro from purified components. During my faculty career, I focused on the study of this RNA-geared biomotor. Our research has led to three major advances: 1) Discovery of a third type of biomotor by revolving mechanism without rotation; 2) Insertion of the motor channel into membrane to serve as a robust nanopore; and 3) promotion of the emergence of a new field of RNA nanotechnology.  I will present the translation of these three findings into industrial and biomedical application including cancer therapy, earlier disease diagnosis, single chemical and protein detection, single pore for high throughput DNA sequencing, potent drug development, and other applications in material science, biocomputer modules, and nanomedicine.
Reference: Guo et al. 1). Science 1987, 236:690; 2) Mol. Cell 1998, 2:149; 3) EMBO J. 2007, 26:527; 4) Nature Nanotech. 2009, 4:765; 5). Nature Nanotech. 2010, 5:833; 6). Nature Nanotech. 2011, 6:658; 7). Nano Today 2013, 8:56; 8). ACS Nano 2015, 9:9731; 9). Nano Today 2015, 10:631.  Advanced Material, 2016. Small, 2016,