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Name of the speaker: Xiaorong Xu
Position: Professor                                   
Organization: University of Science and Technology of China
 Nationality: China
 



The Title of Speech: Mutifunctional micro and nanobubbles for image-guided drug delivey
Biography of the Speaker: Dr. Xu earned a B.S. degree in Precision Engineering from University of Science and Technology of China, a M.S. degree in Mechanical Engineering from State University of New York at Stony Brook, and a Ph.D. in Mechanical Engineering from Massachusetts Institute of Technology, followed by a postdoctoral training at Stanford University. He is currently Professor and Chair of Precision Machinery and Instrumentation at University of Science and Technology of China, and Associate Professor of Biomedical Engineering at The Ohio State University. His teaching and research interests include medical device design, biomedical imaging, microencapsulation and three-dimensional printing, with over 80 technical publications. In 2010, he was honored as one of the 10 brightest Central Ohioans by Columbus CEO Magazine. In 2011, he was awarded the TechColumbus “Inventor of the Year” Award. In 2015, he was nominated as Fellow of Institute of Physics.
 Abstract of Speech: Many chemotherapeutics strategies are based on the enhanced permeability and retention (EPR)effect that suffers from multiple limitations such as lower drug delivery efficiency, dose-limiting cytotoxicity and the development of chemoresistance. We develop novel micro and nanoencapsulation processes to produce multi-layered micro/nanoparticles and stimuli-responsive micro/nanodroplets for sustained drug release and controlled drug delivery with the enhanced safety and efficacy. Sustained drug release and combinatory therapeutic effects are achieved by encapsulating multiple therapeutic and imaging agents in biodegradable micro and nanocapsules. Encapsulating photosensitizers, magnetic nanoparticles, or acoustically responsive materials in stimuli responsive micro/nanodroplets further enables controlled drug delivery and selective drug release at the designated tissue site and with quantitative imaging guidance. The proposed micro/nanoencapsulation processes provide an enabling platform for many novel therapeutic strategies with potentially improved safety and efficacy profiles.